^ Jump up to: a b Resstel LB, Tavares RF, Lisboa SF, Joca SR, Corrêa FM, Guimarães FS (January 2009). "5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats". British Journal of Pharmacology. 156 (1): 181–8. doi:10.1111/j.1476-5381.2008.00046.x. PMC 2697769. PMID 19133999.
Hey Yani- I’m up in WA and had acquired a topical oil made by a friend that worked wonders on angry joints. I know they started from leaf to create. I’m not capable of doing that and am wondering if you have recommendations for resources how to make my own salve from concentrate. I make my own coconut oil/essential oil mixtures already… I’m just not entirely certain where to started with adding in CBD/THC.

Cannabidiol (CBD), a non-psychoactive segment of the marijuana plant, has created huge enthusiasm among researchers and physicians.  CBD Oil applies its remedial effect on an atomic level is as yet being sorted out. Cannabidiol is a pleiotropic sedate in that it produces numerous impacts through various atomic pathways. CBD Oil acts through different receptor-free channels and by official with various non-cannabinoid receptors and particle channels.

Liquid CBD Oil/Tinctures/Extracts: Drops or tinctures should have a “suggested serving size” and the total milligrams of CBD listed on their packaging. From there, you can determine the amount of CBD you would like to ingest. Simply place the correct quantity of drops under your tongue using the dropper and hold the CBD oil in place for a minimum of 60 seconds. The 60 second hold allows for absorption via the blood vessels underneath your tongue – efficiently bypassing first-pass metabolism. Once 60 seconds has passed, swallow the CBD oil.
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First, let’s look at the differences between the plants that make CBD oil.  To start with, the two plants look physically different.  This is due to the different reasons that both of them are grown.  Cannabis, grown for its flowering buds for reasons of smoking or THC extraction, are generally short and wide.  Hemp, on the other hand, is tall and narrow as it is not grown for its buds. Hemp is low in THC and is often grown for a variety of purposes including the manufacture of materials.
There’s a growing body of scientific evidence to support the use of topical CBD products to ease pain, inflammation, and the symptoms of arthritis. One study using rats found that topical CBD has “therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.” More scientific research on humans is needed to confirm all of CBD’s benefits, but the initial research into topical use in humans is also promising.
A 2016 review of animal studies indicated that cannabidiol has potential as an anxiolytic for relief of anxiety-related disorders and fear.[11] Reviews of preliminary research showed cannabidiol has potential for improving addictive disorders and drug dependence, although as of 2016, they indicated limited high-quality evidence for anti-addictive effects in people.[94][20][95]
Given the degree to which marijuana and cannabinoid derivative use has been stigmatized in the past, their Schedule I classification as illegal substances, and lack of FDA approval, valid medical research on the effects of CBD isn’t as plentiful as it should be. Much of the anecdotal evidence, however, suggests that CBD’s neuro- protective, analgesic, and anti-inflammatory effects with regard to topical applications are promising.2

…..i have an aggressive form of heart disease (atherosclerosis) and my on-line research into medical marijuana has uncovered that there are 2 main forms of canabidiol, CBD 1 and CBD 2. Current research is indicating that CBD 1 promotes the growth of arterial plaque while CBD 2 inhibits this growth. Thus, I would like to use a strain that is high in THC and high in CBD 2 with no CBD 1. Is there anything out there with this combination (THC/CBD2) ?? Thanks !!

In the last 6 months, I have been experimenting with CBD & THC to treat the aforementioned. It’s been an expensive experiment with some improvement, just not enough relief from the pain. I’m currently using 75 mcg of fentanyl transdermal, 30 mg Oxycodone 5x daily, muscle relaxers, arthritis pills, etc and they still don’t get me out of bed most days.
I have sporadic back spasms for year I see a chiropractor monthly for maintenance (it help) and deal with daily Knee & hip joint pain due to my job (heavy mechanic/steel work with lots of walking). after reading all the great reviews on CBD oil I want to get off the daily ibuprofen regiment and try CBD oil. I would like to try it as a gel cap but would like some advise on dosage size. I also want to know how often I should take the CBD treatments. any and all advise is appreciated
INGREDIENTS: ALCOHOL DENAT., HAMAMELIS VIRGINIANA (WITCH HAZEL) WATER, WATER (AQUA), PROPYLENE GLYCOL, ALCOHOL, LIDOCAINE, POLYSORBATE 20, GLYCERIN, CANNABINOID EXTRACT, ARNICA MONTANA FLOWER EXTRACT, ALOE BARBADENSIS LEAF EXTRACT, EUCALYPTUS GLOBULUS LEAF OIL, MENTHA PIPERITA (PEPPERMINT) OIL, CAMPHOR, MENTHOL, TOCOPHERYL ACETATE, ALLANTOIN, SODIUM BENZOATE, POTASSIUM SORBATE.
The ointment is made from infusing high-quality cannabis flowers in some kind of quality oil—coconut or olive typically—which extracts the active compounds, either CBD, THC, or both depending on the type of hemp used. This oil is then blended with other therapeutic herbs, like arnica or lemongrass essential oils, that are well-known pain relievers.
Let’s not compare what’s happening to hemp to common sense. Let the state try to tell about 90% of the population that CBD is now banned. I see it as an advertisement. Well that and the lawsuit I will be filing in federal court. Once again we have proof that the BCC is in violation of Business Code 26013-14. They have hijacked prop 64 and are systematically gutting and delivering it to the large players. The entire board needs to be fired and replaced with an industry board. The two union members are ok, but the rest got to go. It says a lot when the good part of the board are the unions and the rest are the appointed assassins.
Can CBD oil help anxiety? Cannabidiol (CBD) is a chemical occurring in cannabis plants. It is possible to add CBD oil to food, and an increasing amount of evidence suggests that it may improve mental health, particularly anxiety. It does not seem to have adverse side effects, but CBD oil is illegal in some states. Learn more about CBD oil here. Read now
Although CBD seems destined to play an important role as a therapeutic agent for a growing number of medical indications, we should seriously ask ourselves if the current unregulated production and sale of CBD oils is done responsibly. Despite the fact that CBD is mainly sold as “just” a food supplement, it is often used by severely ill people with the intention of improving their body functions in a way that their standard medication could not. This obviously puts CBD uncomfortably close to the realm of medicines. Interestingly, the WHO, based on a review of available scientific data and input from international experts, recently concluded that CBD does not immediately require rescheduling as a drug [38], although a fuller review on the risks and benefits of CBD is still being planned. Nevertheless, perhaps the use of CBD products should be assessed in a broader perspective, to cover all ingredients used in the preparation, as well as any contaminants that are already known to be common in recreational cannabis.
I suffer with migraines, fibromyalgia, and arthritis. I pretty much hurt anytime I move. I’m on a regimen of meds, but ordered the Virgin Cannibis Hemp Oil (off of Amazon) and have had it two days. I took 3 tablespoons a day, gagging it down. I couldn’t bring myself to take it today, but I didn’t notice a difference after the second day, and I suppose I would notice something. Was it too soon, or should I be trying a different product? I really need something to alleviate the level of pain during movement, as it’s causing me to be more sedentary.
An important factor is the quality and purity of our CBD. We chose the Kentucky farm collective because of the quality of the hemp plants being grown under the Federal Farm Bill and in conjunction with the Kentucky Agricultural Department Hemp Pilot Program. There are very specific guidelines for planting, growing and the processing of the CBD isolate. As a result, the quality of the CBD produced from the whole plant is some of the purest available. We take great pride in providing our clients with an extremely pure, clean and high-quality product to those who desire CBD. Each and every product that leaves the facility is third-party tested to ensure consistency and quality.
“CBD inhibits the cytochrome P450 enzymes that break down important psychiatric drugs,” says Blessing. CBD isn’t the only substance that messes with the body’s ability to metabolize these drugs — both St. John’s wort and the humble grapefruit are unfriendly — but CBD is comparatively poorly studied. The way CBD inhibits those enzymes could dramatically raise the levels of SSRIs or opioids in the system, potentially leading to an overdose.
On a sunny but unseasonably freezing April afternoon in New York, I walked the 10 or so minutes from the L train to Caffeine Underground, a coffee shop in Bushwick that triples as an art gallery and community center. The open-concept space serves lattes and espressos and a variety of milks (oat, almond, macadamia) and plenty of “wellness” options (Kava tea, Bulletproof-style coffee, activated charcoal add-ins). But there’s one totally unique item: Cannabidiol-infused (CBD) coffee.

FAAH breaks down and removes natural endocannabinoids. CBD stops this breakdown and in turn increases the natural endocannabinoids available to the body. Because endo- cannabinoids have a balancing and healing effect on the body’s numerous systems and functions, CBD’s ability to increase the amount of endocannabinoids available to the body may create a bevy of therapeutic benefits5

The next morning, I blended the contents of the bottle up with collagen (because I add Vital Proteins to pretty much everything I drink) and took my first sip. I was immediately impressed with the taste—so creamy, dreamy, delicious, and not at all skunky. Settling into my couch with my laptop (lazy Sunday mornings are when I like to get myself organized for the upcoming work week), I continued to sip. Normally, and as it would for anyone, diving into my inbox, scanning the upcoming week's calendar, and plotting out all my upcoming to-dos sends shivers of nerves and anxiety down my spine. I love my job, but it comes with its fair share of stress. Miraculously, however, I felt calm, cool, and collected. As my fingers skipped away at lightning speed on my keyboard courtesy of that 80 milligrams of caffeine, I didn't have the usual side effect of nerves, jumps, or jitters. I felt good, and on my way home from the gym later that day, I picked up a couple more bottles of Kickback. What can I say? I was high for it. Of course, "high" not to be taken literally, as CBD—aka cannabidiol—is a non-psychoactive compound of cannabis.
A 2017 article published by the National Academies of Sciences, Engineering and Medicine conducted a study in which the results concluded, “In adults with chronic pain, patients who were treated with cannabis or cannabinoids are more likely to experience a clinically significant reduction in pain symptoms.” This statement is quite a massive development for the increasing of tolerance towards CBD and CBD based products.
The 2016 European Journal of Pain conducted a study on rat models to test the effectiveness of CBD against arthritis in order to see if it could serve as an all-natural alternative to the typical arthritis pain medications, which are often tied with numerous uncomfortable and frustrating side effects. The rats were treated for 4 days with 4 different doses of CBD gel, and the results were quite staggering.
This is a topic I am asked about all the time, and have been for years: how does cannabis help sleep and health? I’ve heard that the number-two reason why people smoke or use cannabis is for sleep. Considering the recent passing of the recreational use of cannabis in California and other several states I think it is high time (pun intended!) to look at understanding CBD, one of the most active ingredients in medical cannabis.

The exact legality of CBD is tricky. The Drug Enforcement Administration maintains that CBD is federally illegal but will not bother going after anyone for possessing or using it. Many argue that a provision in the 2014 farm bill allowing industrial hemp pilot programs, mostly aimed at the textile industry, actually makes non-THC use of cannabis legal; the much-delayed 2018 farm bill would make CBD and industrial hemp legal nationwide if passed as it stands.

There are two preventative procedures you should be taking if you want to keep your skin as youthful for as long as possible: wear sunscreen and wear anti-aging cream at night. Unfortunately, I couldn’t source a reputable sunscreen with CBD, so you’ll have to trust me on the face cream, instead. This organic hemp CBD—sourced from Colorado—and vitamin E oil-enriched formula is too rich for daytime use (unless you have very dry skin and you don’t live in a humid climate), but it’s the perfect luxe treatment to massage into your face and neck before bed every night. After a week of wearing this cream every night, I, a very cystic acne-prone person, did not have any breakouts and had noticeably softer skin in the morning.
I tried a high CBD caplet with no THC. Unfortunately, I found it to be ineffective as a sleep aid, although it eases my chronic pain. Therefore, I take it when I arise for the day. I found an over-the-counter (Washington State) tincture called “beauty sleep” is working for me as a sleep aid. It costs me about $3.00 per night. It tastes yucky, but it works. I put two droppers full of the tincture under my tongue and keep it there for as long as I can before swallowing it. I am able to sleep about 7 hours per night with only one interruption to use the bathroom. This tincture contains 57% THC, which I was trying to avoid, but it is worth it. I do not use it to fall asleep, but to stay asleep. I wait to take it until I am really sleepy. It takes about 90 minutes for it to take effect, which is when I am already sleeping. Without it, that is about when I would be waking up and not being able to get back to sleep. If I take it before I am really sleepy, it just gives me the munchies and I do not need the extra calories. I feel kind of stoned when I wake up to pee, but I get back to sleep a lot better than I did before I started using the tincture. I have not built up a tolerance to it (so far) which is a concern because I do not want to be needing increasingly more as time goes by.. I have been using it for about four months now and am hopeful that it will continue to be effective without needing to increase the dosage. Maybe BEAUTY SLEEP will work for you. It sure has improved my quality of life. Now I am not so narcoleptic and low-energy during the day. Good luck finding a solution to your sleep issues.
If you read the ingredient list, often everything in the jar is straight from mother earth. As long as that's indeed the case with the cream you have your eye on, the formula is immensely safe, chemically, says Gregory Gerdeman, Ph.D., neurophysiologist who researches cannabinoid biology and pharmacology at Eckerd College in Saint Petersburg, FL.. And since they're formulated to be topical—absorbing into the top layer of skin—and not transdermal—which would pass through the skin and into your bloodstream—there's no risk of getting high, Gerdeman explains. (P.S. Here's How Marijuana Affects Athletic Performance.)
Cannabidiol is insoluble in water but soluble in organic solvents such as pentane. At room temperature, it is a colorless crystalline solid.[44] In strongly basic media and the presence of air, it is oxidized to a quinone.[45] Under acidic conditions it cyclizes to THC,[46] which also occurs during pyrolysis (smoking).[47] The synthesis of cannabidiol has been accomplished by several research groups.[48][49][50]
Using an oil tincture, Jamroz devised a crude, homemade CBD coffee concoction back in 2012 in order to find daily pain relief from a couple of slipped discs that he suffered during a snowboarding mishap. While the brew was relatively effective in terms of pain management, he claimed that the original cup tasted something like “hot, grassy swamp water.”

Each and every bottle is grown and processed with the same standards as the last guaranteeing quality and assuring potency. Made from CBD rich hemp flower sun grown in Oregon and MCT oil, Rosebud is proud to be a Vegan, Gluten Free, Non-GMO, Organic, and Sustainably Processed CO2 extract. Choose between our three potencies: 350mg, 700mg and 1000mg. 


I was diagnosed with fibromyalgia,chronic pain and arthritis a few years ago. I suffer 24/7 with pain all over my body. I’ve also been diagnosed with type two diabetes last month . I’m at my whits end with everything,the amount of medication and the things I’ve had to give up. A doctor over heard what my condition was and suggested i try cbd as it doesn’t contain thc and could be quite beneficial for me. My trouble is i’m in the UK and our law is very outdated and cbd isn’t as easy to get hold of. It’s not like i can just walk into a chemist and pick some of the shelves. Can anyone recommend someone or somewhere i can obtain this cbd to try and see if it helps me. I’ve been told you can get it to put in an ecig which would be useful as i use them. Thank you and sorry if i dragged on

I just started taking CBD oil , I am on my 2nd Hip replacement surgery due to device failures looking at a 3rd surgery. Has you can imagine the pain, stress and anxiety levels are off the charts. Especially at an otherwise healthy 54 yr women. So i understand from reading posts its best to take it under the tongue. I am taking 1-2 ml a day. I can tell some difference,is your recommended dosage. I am using for pain , stress and sleep. I appreciate your feedback.


One of the strongest nutraceutical CBD oils is called Charlotte’s Web, with a 50mg dose. Charlotte’s Web is produced in Colorado by the Stanley Brothers, and named after Charlotte Figi, a girl who became famous in the US after her frequent seizures, brought on by the rare Dravet syndrome, were greatly reduced when she started taking CBD oil aged five. The company makes THC products too and is extremely successful, having just offered shares on the Canadian securities exchange, raising about $100m.
Let’s give them a few months to correct the damage before we have to do another “real public initiative” . One without Gavin Newsome or any other politician attached to it. Prop 64 required a five year phase in before the big money players mess up our simple plant, in back room dealings. Now I think five is not enough. We can go back to the voters and ask for a good common sense cannabis program. About three pages of rules listed right in the law. Even with just three pages of regulations we can assure that cannabis does less harm than, (insert any drug or food item here).
I recently discovered Après and have quickly become obsessed. I like to make sure I start my morning with protein, fiber, and fat, and their signature recipe features all of the above. Plus, it makes for a yummy and sturdier base for my favorite cold brew than just water or almond milk, my previous standbys. All of the flavors are great, but since the CBD oil I love is mint chocoate–flavored, I opt for the like-minded flavor of Après. Post-coffee and -ice, it's like a magical mint-chocolate shake that simultaneously wakes me up and calms me down. Kind of perfect, no? 

A THC-rich rub infused with cooling menthol and peppermint is a perfect way to wind down from a brutal workout or hike. For intense localized pain, you may try a warming balm that combines the deep painkilling properties of cannabinoids with a tingling, soothing sensation. Inflammation symptoms may require a different chemical profile, as Cannabis Basics’ CEO Ah Warner explains:
For pain management, both topical and oral CBD work well, typically proving the most effective relief when utilized together. Oral CBD also assists in the diminishing of symptoms from anxiety, depression and other mental disorders, as well as insomnia. Topicals work brilliantly at reducing inflammation, arthritis, headaches, cramping and migraines, and some evidence has shown that it can also heal eczema, psoriasis, dermatitis and itching.

This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Individual weight loss results will vary. By using this site, you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited by Law.
Reasonably, many individuals research their information on the internet; however, some of the information found online can be misleading. CBD is still a relatively new field and we’ve noticed many reported misconceptions. CBD oil, hemp oil, THC oil, cannabis oil, and marijuana oil all refer to oils coming from the cannabis plant. However, they differ in how they are grown, extracted, and used. In this blog post, we will discuss the differences between these terms in hopes of educating the public and helping people gain a more beneficial understanding.
Selective breeding of cannabis plants has expanded and diversified as commercial and therapeutic markets develop. Some growers in the U.S. succeeded in lowering the proportion of CBD-to-THC to accommodate customers who preferred varietals that were more mind-altering due to the higher THC and lower CBD content.[58] Hemp is classified as any part of the cannabis plant containing no more than 0.3% THC in dry weight form (not liquid or extracted form).[59]
Even some of the claims made by recreational CBD sellers aren’t bullshit, in the abstract. CBD really does show some anti-inflammatory properties. It really does have anxiolytic effects, in certain situations. Of course, it’s the scammy nature of herbal supplements that a seller can say something like “CBD has been indicated to reduce anxiety” (a true statement!), even though the actual product you’ve got in your hand has never been indicated to do so. Nutmeg, for example, will act as a dangerous psychoactive drug at high levels, but it would be deranged to put “scientific research has shown that nutmeg can get you high as hell” on a pumpkin spice latte. It’s correct, but it’s also incredibly misleading.
CBD products have become increasingly popular in recent years, as more and more producers market CBD as the new "it" drug for the health and wellness set — one that has been touted as a pain reliever and a treatment for anxiety, among other potential applications. Last year, consumer sales of CBD products topped $350 million in the United states, more than triple the amount sold in 2014, and various estimates predict the market could reach $2 billion within the next two to four years.
The 2016 European Journal of Pain conducted a study on rat models to test the effectiveness of CBD against arthritis in order to see if it could serve as an all-natural alternative to the typical arthritis pain medications, which are often tied with numerous uncomfortable and frustrating side effects. The rats were treated for 4 days with 4 different doses of CBD gel, and the results were quite staggering.
The CDPH memo adds to the confusion by drawing a distinction between “hemp” and “cannabis” — even though hemp is a form of cannabis. If it weren’t, you wouldn’t be able to derive CBD from it. Avoiding this confusion is part of the case for not purging the word “marijuana” from the English language, despite the stigma increasingly associated with the word.
Larilyn, Great question. Most CBD oils are hemp-derived, which, by definition, means they generally contain 0.3 percent THC. That being said, there is no way to guarantee that a person will pass a UA screening due to variables within that persons composition & other influences. Some people will turn to a isolate version zero percent THC of CBD for this reason but in doing so will not reap the benefits of full spectrum. I prefer the option of Enterouge oil for these candidates.
A 2017 article published by the National Academies of Sciences, Engineering and Medicine conducted a study in which the results concluded, “In adults with chronic pain, patients who were treated with cannabis or cannabinoids are more likely to experience a clinically significant reduction in pain symptoms.” This statement is quite a massive development for the increasing of tolerance towards CBD and CBD based products.

We never knew that cannabis oil can cure cancer, if not my lovely and adorable husband wouldn’t have die of his prostate cancer, well all the same i still give God all the glory and big thanks to Dr Rick who provided me with CANNABIS oil for my son liver cancer, after i lost my husband to prostate cancer 2 years later my son was diagnosed with cancer of the liver he under-go many chemo’s and radiation treatment in seeking solution to cure the liver cancer i spent all i have but all to no avail until i mean’t a friend of mine who directed me to Rick Simpson Cannabis Oil via Email: phoenixtearsoil5@gmail.com
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