^ Nadulski T, Pragst F, Weinberg G, Roser P, Schnelle M, Fronk EM, Stadelmann AM (December 2005). "Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract". Ther Drug Monit. 27 (6): 799–810. PMID 16306858.
Last year, the National Academies of Sciences, Engineering and Medicine released a nearly 500-page report on the health effects of cannabis and cannabinoids. A committee of 16 experts from a variety of scientific and medical fields analyzed the available evidence — more than 10,000 scientific abstracts in all. Because so few studies examine the effects of CBD on its own, the panel did not issue any findings about CBD specifically, but it did reach some conclusions about cannabis and cannabinoids more generally. The researchers determined that there is “conclusive or substantial evidence” supporting the use of cannabis or cannabinoids for chronic pain in adults, multiple sclerosis-related spasticity (a kind of stiffness and muscle spasms), and chemotherapy-induced nausea and vomiting. The committee also found “moderate” evidence that cannabis or cannabinoids can reduce sleep disturbances in people with obstructive sleep apnea, fibromyalgia, chronic pain and multiple sclerosis, as well as “limited” evidence that these substances can improve symptoms of Tourette’s syndrome, increase appetite and stem weight loss in people with HIV/AIDs, and improve symptoms of PTSD and anxiety.
In any case, California’s decision to ban CBD oil from hemp seems like it may be informed more by legalistic hair-splitting. And to illustrate how finely that hair is split, recall that CBD is a controlled substance under federal law, regardless of what it is derived from. Yet federal policy is also contradictory. The FDA’s recent approval of the CBD medicine Epidiolex comes despite the fact that the DEA considers CBD a Schedule I substance, with no medical applications. A DEA rescheduling or de-scheduling of CBD would go a long way toward resolving these questions — and is coming in the next three months.
A THC-rich rub infused with cooling menthol and peppermint is a perfect way to wind down from a brutal workout or hike. For intense localized pain, you may try a warming balm that combines the deep painkilling properties of cannabinoids with a tingling, soothing sensation. Inflammation symptoms may require a different chemical profile, as Cannabis Basics’ CEO Ah Warner explains:
Then there’s the issue of vomiting and nausea after chemotherapy. Most people that underwent chemo know that there is proper medication for these side effects. However, these meds often don’t achieve the desired effect. It’s no wonder that people are looking for alternatives like CBD. During one study, 16 participants that had chemo treatment used a CBD-THC combination. This combo was administered through a spray. Nearly all participants agreed that this helped lower vomiting and nausea.
In just a few years, cannabidiol (CBD) has become immensely popular around the world. After initially being discovered as an effective self-medication for Dravet syndrome in children, CBD is now sold and used to treat a wide range of medical conditions and lifestyle diseases. The cannabinoid CBD, a non-psychoactive isomer of the more infamous tetrahydrocannabinol (THC), is available in a growing number of administration modes, but the most commonly known is CBD oil. There are currently dozens, if not hundreds, of producers and sellers of CBD oils active in the market, and their number is increasing rapidly. Those involved vary from individuals who prepare oils on a small scale for family and (Facebook) friends to compounding pharmacies, pharmaceutical companies, and licensed cannabis producers. Despite the growing availability of CBD, many uncertainties remain about the legality, quality, and safety of this new “miracle cure.” As a result, CBD is under scrutiny on many levels, ranging from national health organizations and agricultural lobbyists to the WHO and FDA. The central question is whether CBD is simply a food supplement, an investigational new medicine, or even a narcotic. This overview paper looks into the known risks and issues related to the composition of CBD products, and makes recommendations for better regulatory control based on accurate labeling and more scientifically supported health claims. The intention of this paper is to create a better understanding of the benefits versus the risks of the current way CBD products are produced, used, and advertised.
Despite this, CBD is something nobody knows much about, and certainly nobody is monitoring it properly. CBD is widely marketed as a supplement, despite the Food and Drug Administration saying it does not qualify as such (this is because it is an active ingredient in drugs which are either approved or under investigation to be approved). CBD goes largely unregulated by the agency; on the FDA’s FAQ page, a vague answer maintains there are “many factors in deciding whether or not to initiate an enforcement action.” The Department of Agriculture handles research grants and pilot programs for hemp, but that’s where its involvement ends.
Cannabis has been used medicinally for centuries, as a sleep aid, a pain and nausea reducer, to relieve anxiety and other mood problems. In the mid-1960s, scientists identified the first cannabinoid. Since then, scientists have gone on to identify more than 80 individual cannabinoids and continue to investigate them for their potential symptom-relieving and disease-fighting abilities.
A non-intoxicating, highly therapeutic compound in cannabis known as CBD, or cannabidiol, has sparked a revolution in cannabis. Studies have demonstrated CBD’s benefits in treating a variety of ailments, including epilepsy, cancer, pain, arthritis, and anxiety disorders, although it can also be used to alleviate everyday stress and more mild symptoms.
If the ECS is affected, or the body is not producing enough endocannabinoids, these functions in the body may become unbalanced. And when the body is not producing or regulating endocannabinoids properly, ingesting natural cannabinoids or applying them topically can restore this balance. CBD differs from THC in the sense that THC mimics the natural cannabinoids in the body and binds with the cannabinoid receptors CB1 and CB2, which are found in abundance within the immune system, the gastrointestinal tract, and in the central and peripheral nervous systems. While THC binds to these receptors, CBD interacts with an enzyme called FAAH (fatty acid amide hydrolase).4
Cannabis-infused topicals have become a popular item among patients treating a variety of aches and pains. Applied directly to the skin, topicals deliver localized relief and often contain a variety of therapeutic compounds, not just CBD. Because balms and salves are non-intoxicating, topicals are a great choice for patients needing relief with a clear head.
SteepFuze Hemp Cannabinoid Coffee – Spring Release Spring Release begins with Ethiopian Yirgacheffe, one of the most popular beans in the coffee world, sourced from the mountains of the Sidama region of southern Ethiopia. Spring Release beans are delicately roasted to a medium level to preserve the natural sugars and sweetness. The beans are infused with […]
“Among the many benefits that Charlotte’s Web customers experience are: a sense of calm and focus; relief from everyday stresses; help in recovery from exercise-induced inflammation; and support for healthy sleep cycles,” says co-founder Jesse Stanley. But he is obliged to point out that the product is a dietary supplement, and no clinical claims can be made for it.
I live in Utah so I have no way to get Harlequin CBD. Is there anything even close to that, that doesn’t need a medical card to purchase. There are so many BS CBD hemp companies that are not trustworthy and I don’t want to waste anymore money trying to find something. My son loves his school or we would have moved already. Help! I need a legit CBD hemp company to buy tincture and capsules. Leafy is my go to because so far all the info always checks out.
Hi Colleen, it's almost a year later and I'm wondering how you're doing. I'm experiencing a recurrence of Stage 3 ovarian, originally diagnosed in 2011. I've decided to get some chemo, not sold on another 6 cycles though. As a new MMJ patient, I'm still going to go through with Rick Simpson Oil (THC+CBD,) and I just joined a program with my local dispensary to get CBD capsules for $2 each when I order them at least 30 at a time. I hope you're doing well!! I'm off to do more research on dosing. **NOTE: If you have ANY experience with CBD treatment of ovarian cancer, PLEASE respond. Thank you!!
“Placebo response always needs to be taken into account for any treatment being studied,” says Baron. “Placebo response is actually quite high in many pharmaceutical trials, for example. In fact, there are many treatment trials for various medications and other treatments where benefit responses to placebo are actually higher than the treatment itself being studied.”
I suffer with migraines, fibromyalgia, and arthritis. I pretty much hurt anytime I move. I’m on a regimen of meds, but ordered the Virgin Cannibis Hemp Oil (off of Amazon) and have had it two days. I took 3 tablespoons a day, gagging it down. I couldn’t bring myself to take it today, but I didn’t notice a difference after the second day, and I suppose I would notice something. Was it too soon, or should I be trying a different product? I really need something to alleviate the level of pain during movement, as it’s causing me to be more sedentary.