Unlike with THC, CBD’s effects aren’t limited to that single receptor. These effects are not precisely known, though CBD certainly has some impact on CB1’s sister receptor (CB2) as well as a receptor called 5-HT1A. When the 5-HT1A receptor comes into contact with a material that agonizes it, the effects can include reduced anxiety and increased calmness.
Research suggests that CBD may exert some of its pharmacological action through its inhibition of fatty acid amide hydrolase (FAAH), which may in turn increase the levels of endocannabinoids, such as anandamide, produced by the body.[8] It has also been speculated that some of the metabolites of CBD have pharmacological effects that contribute to the biological activity of CBD.[42]
My husband has RSD and we are considering CBD oil -= I would ask at Hempmed because the spray won't have enough in it. Our dgt';s friend has ovarian cancer and it is shrinking her tumors but the spray would never have been enough. I would get CBD oil and check with Hempmeds to see what they suggest. It isn't cheap but it does work. LOW dose Naltrexone about 4.5 mg is very helpful for RSD and is usually used for getting people off of drugs but is working on turning off the glial cells that surround the nerve that is causing the nerve to scream in pain. We are also using PeaPure that is out of the Netherlands and we are seeing a response, even though small. His other leg touched the painful leg without causing more severe pain. That is progress. We also are using Poison Ivy Cream through Meadowlake Farms that has helped the burning surface pain. Change your diet and get rid of Gluten and Sugar, anything that causes inflammation. This is to allow your own body to work. Absolutely do not use any pain killers as it will turn up your pain. all the Hydrocodone, etc causes neural inflammation and so it will keep cascading higher your pain. Hope this is helpful. Mary
My mother has been on pain killers for a failed diagnosis of lymphoedema. After the third day of using this topical on her right arm, the affected area, she has gotten rid of the pain killers and started sleeping better after 2 months of no sleep. She couldn't believe it and neither could I. I just ordered the oils and will most definitely post her successes. Truly satisfied with your product and I hope that the oils are exactly what she needs! ? thank you
…..i have an aggressive form of heart disease (atherosclerosis) and my on-line research into medical marijuana has uncovered that there are 2 main forms of canabidiol, CBD 1 and CBD 2. Current research is indicating that CBD 1 promotes the growth of arterial plaque while CBD 2 inhibits this growth. Thus, I would like to use a strain that is high in THC and high in CBD 2 with no CBD 1. Is there anything out there with this combination (THC/CBD2) ?? Thanks !!
If you read the ingredient list, often everything in the jar is straight from mother earth. As long as that's indeed the case with the cream you have your eye on, the formula is immensely safe, chemically, says Gregory Gerdeman, Ph.D., neurophysiologist who researches cannabinoid biology and pharmacology at Eckerd College in Saint Petersburg, FL.. And since they're formulated to be topical—absorbing into the top layer of skin—and not transdermal—which would pass through the skin and into your bloodstream—there's no risk of getting high, Gerdeman explains. (P.S. Here's How Marijuana Affects Athletic Performance.)
CA already has its hands full (poorly) implementing it’s legal marijuana laws, it’s doubtful whether there is time, money or political willingness to go into retail stores and remove a product that’s federally legal to sell and own based on the Hemp Farm Act of 2014. It’s also poorly written (as referenced in the article). I agree with the poster that this has to be politically or financially driven.
CBD from hemp is identical chemically and therefore will cure cancer equally as well. The difference in effectiveness would be more whether it is a full spectrum product vs an isolate. As hemp does contain some THC, hemp derived CBD can be full spectrum. What you are saying is equivalent to citrus from an orange is better for colds than citrus from limes. As w CBD citrus is citrus (chemically identical) regardless of the source.

I wanted to tell people here that CBD has been very effective for my anxiety, and helps with insomnia. For me, it was a cumulative effect, after a week of one dropper of oil, I can sleep very well at night. I feel like I am not polluting my body with commercial pharmaceuticals. I wish everyone here the best, and hope it works for you as well as it has for me.
One study found that placebos sometimes work even when the subject knows it’s a placebo. Another, using that same public speaking setup that CBD studies have used, found that anxiety treatments are particularly susceptible to the placebo effect, with 40 percent of placebo-treated patients showing a decrease in anxiety symptoms while tasked with speaking to a crowd.
As with a fermented food like kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants. Changes in the weather, soil, and water can all impact the biology of the source material. While we verify Certificates of Analysis (and take many other criteria into consideration during our review process), even the most reputable five-star companies have no way to control for every variable in this organic process.
Food and beverage products containing CBD were introduced in the United States in 2017.[54] Similar to energy drinks and protein bars which may contain vitamin or herbal additives, food and beverage items can be infused with CBD as an alternative means of ingesting the substance.[55] In the United States, numerous products are marketed as containing CBD, but in reality contain little or none.[56] Some companies marketing CBD-infused food products with claims that are similar to the effects of prescription drugs have received warning letters from the Food and Drug Administration for making unsubstantiated health claims.[57]
It depends on the dose and the person. Dr. Bonni Goldstein, M.D., the medical director of Canna-Centers, notes that it’s hard to figure out how exactly CBD will affect individuals. “It’s unclear at this point in time the exact interaction between CBD and caffeine,” she says. “At low doses, CBD is a stimulant and in higher doses it can cause sedation....Someone’s reaction to a combination of these compounds would not be easily predictable because various doses of each would affect the response,” Goldstein explains.
Oh, was I just talking about Girl Scout cookies? I prefer showers over baths—we all have an allegiance to one or the other—but we can’t ignore how many memes have come out of #bathbombs. It’s satisfying to watch them fizzle, they turn your bath into fun colors, and they claim to provide aromatherapy benefits, too. They’re also much tidier than traditional bath salt products; just chuck one in and wait!
Let’s give them a few months to correct the damage before we have to do another “real public initiative” . One without Gavin Newsome or any other politician attached to it. Prop 64 required a five year phase in before the big money players mess up our simple plant, in back room dealings. Now I think five is not enough. We can go back to the voters and ask for a good common sense cannabis program. About three pages of rules listed right in the law. Even with just three pages of regulations we can assure that cannabis does less harm than, (insert any drug or food item here).
According to West, who says her team is “drawing on a wealth of anecdotal evidence,” CBD in your java can really take the edge off. “My colleagues, friends, and I have found that CBD-infused coffee largely does away with the anxiety and acid belly typically associated with coffee,” she says. “That makes sense, because research suggests CBD has anti-anxiety and [anti-nausea] effects. We’ve also found that compared to the coffee we reach for regularly, testers experience a less jittery, elevated burst of energy after drinking CBD-infused coffee.”

Out of all the CBD products I’ve tested and used in the past few weeks, this thick green lemon-vanilla scented salve is my favorite. I massage it onto my sore red knuckles after boxing practice, and if it weren’t so expensive, I would encase my entire body in it. The cannabis sativa seed oil in this salve has antioxidant properties so that your skin can repair itself from the inside out, while the thick balm-like formula protects your skin from environmental aggressors. I would not recommend rubbing this onto your face because it’s so thick, but do whatever you want on the rest of your body—and if your feet are in need of some serious TLC in time for summer sandals weather, consider rubbing this onto your cracked heels and putting on a pair of soft socks before bed. The next morning, you’ll have baby’s feet again.


This takes us to the next problem: There is no regulation around how much active CBD or THC is in each cream or how much of the compound is needed to see relief. Read: "If you have three products that say 1 percent CBD infused in coconut oil, one could be great and the other two could be crap—that's the reality of cannabis medicine right now," Gerdeman says.
My grandma has advanced rheumatoid arthritis and osteoarthritis - debilitating pain and inflammation. She's on the 4th failed infusion. Nothing was working to control her pain and inflammation. I purchased the 1000mg mint CBD and the topical. I put the topical on her knees, ankles, shoulders, back, hips, and then gave her 15 1000mg drops. She instantly felt relief with the topical. She said it was a cooling pain relief. The topical smells really good.
Our reviews also include the ingredients and a description of the scent and texture of each CBD topical. We tried to remain neutral in our descriptions of each product, since each consumer’s experience is subjective. These are all high-quality CBD creams, balms and salves, but you may find you prefer one scent over another. You might love or hate menthol. Some people prefer a light texture, while other buyers are looking for CBD topicals to use in a massage.
Each and every bottle is grown and processed with the same standards as the last guaranteeing quality and assuring potency. Made from CBD rich hemp flower sun grown in Oregon and MCT oil, Rosebud is proud to be a Vegan, Gluten Free, Non-GMO, Organic, and Sustainably Processed CO2 extract. Choose between our three potencies: 350mg, 700mg and 1000mg. 
Because it does not produce psychoactive effects and hemp is not a controlled substance, hemp-based products are legal to sell, buy, and possess in all 50 states. However, the law is a bit more complex when discussing CBD oils and other hemp byproducts. According to the 2014 Farm Bill, hemp should only be grown and cultivated for academic research purposes. This means that, technically, any hemp-derived oil that is not grown for these purposes would be illegal — though this law is rarely enforced. To make matters more complex, the laws are somewhat unclear in certain states. Sen. Mitch McConnell of Kentucky recently introduced legislation that would legalize all hemp products at the federal level, but this decision is still pending.
As it turns out, CBD (short for cannabidiol) is a phenomenal natural therapy for literally dozens and dozens of different ailments. General pain relief is probably the single most common reason that people take CBD, but it’s also proven to be extremely effective for psychological conditions like anxiety and depression, as well as for things like chronic seizures/epilepsy, diabetes, migraines, neurodegenerative disease (multiple sclerosis, fibromyalgia), digestive issues, and even menstrual cramps.
So far, I’ve found that in order to feel a marked improvement in pain relief, I need a high dose of CBD (which I have yet to determine due to the unavailability and expense). However, I have found that (edible) THC has allowed me to fall asleep faster and longer compared to prescriptions such as Ambian. It also gives me a feeling of well-being. I went from only sleeping 2-3 nights a week for no more than 4 hrs per sleep, to sleeping 8 hrs per night. This alone is worth using cannabis. As you know, lack of sleep can seriously impact your pain level.

Various strains of "medical marijuana" are found to have a significant variation in the ratios of CBD-to-THC, and are known to contain other non-psychotropic cannabinoids.[61] Any psychoactive marijuana, regardless of its CBD content, is derived from the flower (or bud) of the genus Cannabis. Non-psychoactive hemp (also commonly-termed industrial hemp), regardless of its CBD content, is any part of the cannabis plant, whether growing or not, containing a ∆-9 tetrahydrocannabinol concentration of no more than three-tenths of one percent (0.3%) on a dry weight basis.[62] Certain standards are required for legal growing, cultivating and producing the hemp plant. The Colorado Industrial Hemp Program registers growers of industrial hemp and samples crops to verify that the THC concentration does not exceed 0.3% on a dry weight basis.[62]


Cannabidiol is insoluble in water but soluble in organic solvents such as pentane. At room temperature, it is a colorless crystalline solid.[44] In strongly basic media and the presence of air, it is oxidized to a quinone.[45] Under acidic conditions it cyclizes to THC,[46] which also occurs during pyrolysis (smoking).[47] The synthesis of cannabidiol has been accomplished by several research groups.[48][49][50]
Leafly is the world’s largest cannabis information resource, empowering people in legal cannabis markets to learn about the right products for their lifestyle and wellness needs. Our team of cannabis professionals collectively share years of experience in all corners of the market, from growing and retail, to science and medicine, to data and technology.
Hi I've had rsd over 25 years now and in stage 3 I take cbd I'mor nong 6 weeks now and it's helped tons w my depression,sleep,constipation as well as energy. I take 2 drops under tounge every morning and Rick spson oil 3 xs day.It's bern beyond life changing for me look into the rs oil w the cbd. It works.. I still take 1 opiad a day have taken 2 a day only 3 times in almost 2 months when I was in bad flare ..
Yes, there's a new type of topical ointment on the market, and it's infused with the cannabidiol (CBD) from marijuana. Manufacturers claim it can help alleviate acute pain and muscle soreness. CBD is similar to THC, except it's non-psychoactive, meaning some researchers view it as the golden child of medicinal use. (See also: Personal Trainers Reveal the Products They Use to Relieve Muscle Soreness)

Tammy et al, Through trial and error you will find a correct dosage. Try 50 mg daily....25 each 2x daily....if no results up the dosage until it works for you. Remember, there has never been a death from marijuana or CBD use. You might want to try a tincture or rub with CBD and THC. You won't get the psych high from it. Helps my friend with PArkinsons tremors. She takes 50mg of tincture and uses the rub morning and night. It is a miracle for arthritis. Good luck


The CBD topicals for sale come in many different preparations. Green Roads World offers independent lab testing so that customers know exactly what they are purchasing. Everything from our CBD topical cream to our CBD oil has been professionally tested. Each container of CBD Pain Cream has 150mg of CBD and a menthol infusion. It can be applied every four to six hours as needed. The CBD in all of Green Roads World products is obtained using a CO2 extraction. This utilizes CO2 that has been captured as a liquid state to produce a broad spectrum CBD solution. This extraction method is very clean, efficient and free of contaminants. If a customer wishes to buy CBD cream, they can order online or find Green Road’s products in over 5000 retail locations. Green Roads World offers resources for CBD education and a friendly customer service team to answer any customer questions.
Cannabidiol is insoluble in water but soluble in organic solvents such as pentane. At room temperature, it is a colorless crystalline solid.[44] In strongly basic media and the presence of air, it is oxidized to a quinone.[45] Under acidic conditions it cyclizes to THC,[46] which also occurs during pyrolysis (smoking).[47] The synthesis of cannabidiol has been accomplished by several research groups.[48][49][50]

Let’s not compare what’s happening to hemp to common sense. Let the state try to tell about 90% of the population that CBD is now banned. I see it as an advertisement. Well that and the lawsuit I will be filing in federal court. Once again we have proof that the BCC is in violation of Business Code 26013-14. They have hijacked prop 64 and are systematically gutting and delivering it to the large players. The entire board needs to be fired and replaced with an industry board. The two union members are ok, but the rest got to go. It says a lot when the good part of the board are the unions and the rest are the appointed assassins.
I have digenerative disc disease/4 bulgin discs was taking 9---10mg hydrocodones a day... i started with 3 drops of 300mg and within 5 mins started feeling better than i have theses last 6 years or so... not only that, the inflamation has decrease substantially, i wake up with energy and have begun to work out again... if im making it seem like a miracle drug... its because it is... so the first week i took 3 drops twice a day... now 3 weeks in... im taking about 5 drops 3 times a day and zero pain pills... for the first time in years i have taken control of my life agin... not depending on doctor scripts/bills etc....
Hemp pertains to a strain of Cannabis Sativa that has been bred precisely for oils and topical ointments, fiber used for clothing and construction, nutritional benefits, and a broad thriving variety of other purposes that do not involve the euphoria that is associated with marijuana. Hemp is a fast growing plant and was one of the first plants to be spun into usable fiber more than 10,000 years ago.
“CBD inhibits the cytochrome P450 enzymes that break down important psychiatric drugs,” says Blessing. CBD isn’t the only substance that messes with the body’s ability to metabolize these drugs — both St. John’s wort and the humble grapefruit are unfriendly — but CBD is comparatively poorly studied. The way CBD inhibits those enzymes could dramatically raise the levels of SSRIs or opioids in the system, potentially leading to an overdose.
Our Editor’s Pick is the tincture from CBDistillery. This tincture is available in five strengths ranging from 250mg to 5,000mg, which accommodates a wide range of THC preferences, as well as 15 and 30 milliliter containers. The tincture has a price-point that is slightly below average, making it a good option for value seekers. The tincture, which is non-flavored, routinely undergoes third-party testing to ensure safety and high quality; the testing results are available on CBDistillery’s product pages.
For pain management, both topical and oral CBD work well, typically proving the most effective relief when utilized together. Oral CBD also assists in the diminishing of symptoms from anxiety, depression and other mental disorders, as well as insomnia. Topicals work brilliantly at reducing inflammation, arthritis, headaches, cramping and migraines, and some evidence has shown that it can also heal eczema, psoriasis, dermatitis and itching.
Pro skateboarder Matt Miller, who started CBD brand Miller Healer, turns to CBD sports salve and patches as his primary medicine. Stacy Verbiest, who founded therapeutic women’s cannabis line Wink with creams and tinctures, says CBD helped her friend manage the pain of cancer treatments. Pet owners buy cat and dog treats with the hopes of helping their best friend feel happier and more comfortable.

Hemp Oil contains naturally occurring phyto-cannabinoids, including CBD. It is widely consumed for its numerous wellness properties: as mild analgesic, antiinflamatory, antioxidant and antiemetic to name a few. Sträva uses the finest, full-spectrum hemp oil sourced from respected growers in Europe and Colorado. This oil is naturally rich in phyto-cannabinoids, including CBD, as well as constituents such as amino acids, vitamins B1, B2 and D, omega-3 and omega-6 fatty acids, minerals zinc, calcium and magnesium. Hemp Oil and CBD are non-psychoactive and do not produce a "high."
In most cases (and in all cases in which the coffee shop doesn’t want to risk being sued), coffee shops can’t advertise CBD as doing much of anything, one way or another. While clinical trials attempt to determine an effective dose for a particular condition, says Esther, the growing “wellness empire” is free to leave the effects to your imagination. “People who are selling CBD don’t even have to make specific claims. The relationship between the actual amount of CBD and the effect doesn’t have to be very specific, because there is no specific effect that they’re talking about,” says Blessing. “So if I have a CBD latte, I might feel a little relaxed, or a little less neurotic, or who knows.”
I tell several sellers of CBD food and drink what I learned from Blessing and ask what they think. “Return customers who come back, and swear by it and love it, buy two at a time to stock up for the week because they do find it to be very helpful,” says Tavares. Clancy echoes this: “We rely a lot on consumer feedback and testimonial, and generally it’s positive when taking that minimal amount. Now, that very well could be a placebo effect, but either way, people have come back and reported significant benefits when it comes to easing social anxiety.”
CBD is short for cannabidiol, and it is one of more than 60 compounds found in these plants.  It acts on the body’s endocannabinoid system, creating physical changes in the body, which can be beneficial in many ways.  In recent times, it has become increasingly understood that taking CBD oil, a product made from CBD, can have a positive influence on many aspects of life and health.

It may have something to do with the fact that THC stimulates that CB1 receptor a lot, in turn triggering the psychoactive effects of marijuana like disturbed sensory perception, impaired motor skills, and anxiety. Conversely, CBD stimulates CB1 very lightly, causing some effects that seem downright opposed to those of THC including relief from anxiety, stress, and hyper-excitability.


Cannabinoids are a class of compounds that interact with receptors throughout your body. CBD is just one of dozens of cannabinoids found in cannabis, including tetrahydrocannabinol (THC), which is the one responsible for marijuana’s famous high. Medical cannabis is technically any cannabis product used for medicinal purposes, and these can contain THC or CBD or both, said Nick Jikomes, a neuroscientist at Leafly, a website that provides information about legal cannabis. “A common mistake people make is to think that CBD is ‘the medical cannabinoid’ and THC is ‘the recreational cannabinoid.’” That’s inaccurate, he said, because THC is a potent anti-inflammatory and can be helpful for pain.
I used a “cbd tincture 250mg”. After about 3 weeks I started passing blood and protein in urine. I stopped and it cleared up. A couple weeks later I decided to try again and within 3 days it happened again. Could this be due to the type of oil I used or might I have the same problem with any oil I try? It was helping my hip pain and crohns. Thanks!
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